On saline diuresis

Differences between Saline and Mannitol Diuresis in Hydropenic Man.

Effectiveness of normal saline diuresis in treating lithium overdose.

Lithium carbonate is a common treatment for mood disorders, but it has a very narrow therapeutic index and can be toxic to multiple organ systems. Unfortunately, many patients suffer toxic effects through the course of their therapy. We describe a patient with toxic effects from a high dose of lithium who was successfully treated with normal saline diuresis. We discuss the properties that make ...

Effect of osmotic and mercurial diuresis on simultaneous water diuresis.

A VARIETY of mechanisms have been proposed to explain the dilute urine excreted in water diuresis. Cushny (I) and Smith (2) may be consulted for references to the older literature. Theoretical concepts which have been current in recent years will be considered in more detail in the discussion at the end of this paper. The experiments reported here were devised to test the degree to which water ...

Free water clearance curves during saline, mannitol, glucose and urea diuresis in the rat.

1. Free water clearances were measured during infusion of hypotonic saline, glucose, urea, and mannitol in Brattleboro rats. For each solute the free water clearances were plotted using either V or (C(H2O) + C(Na)) as the distal tubular delivery term.2. In all cases the use of (C(H2O) + C(Na)) as distal delivery term yielded a steeper relationship than when V was used. There were no significant...

Renal Tubular Transport of H-Digoxin in Saline Diuresis in Rats Evaluation by Micropuncture

We evaluated urinary excretion and tubular transport of H-digoxin by three different methods in anesthetized rats made diuretic by infusion of 2.5% saline. In one group small volumes of H-digoxin and "C-inulin were injected simultaneously into surface proximal convolutions, and urine was collected serially from both ureters. Digoxin recovery was lower after early (62.1 ± 5.3%) than after late (...